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Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma
Joint Authors
Zhang, Huairong
Gao, Bo
Shi, Bingyin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
We aim to identify protein kinases involved in the pathophysiology of papillary thyroid carcinoma (PTC) in order to provide potential therapeutic targets for kinase inhibitors and unfold possible molecular mechanisms.
Materials and Methods.
The gene expression profile of GSE27155 was analyzed to identify differentially expressed genes and mapped onto human protein kinases database.
Correlation of kinases with PTC was addressed by systematic literature search, GO and KEGG pathway analysis.
Results.
The functional enrichment analysis indicated that “mitogen-activated protein kinases pathway” expression was extremely enriched, followed by “neurotrophin signaling pathway,” “focal adhesion,” and “GnRH signaling pathway.” MAPK, SRC, PDGFRa, ErbB, and EGFR were significantly regulated to correct these pathways.
Kinases investigated by the literature on carcinoma were considered to be potential novel molecular therapeutic target in PTC and application of corresponding kinase inhibitors could be possible therapeutic tool.
Conclusion.
SRC, MAPK, and EGFR were the most important differentially expressed kinases in PTC.
Combined inhibitors may have high efficacy in PTC treatment by targeting these kinases.
American Psychological Association (APA)
Zhang, Huairong& Gao, Bo& Shi, Bingyin. 2016. Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103677
Modern Language Association (MLA)
Zhang, Huairong…[et al.]. Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103677
American Medical Association (AMA)
Zhang, Huairong& Gao, Bo& Shi, Bingyin. Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103677