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Uroplakin II Expression in Breast Carcinomas Showing Apocrine Differentiation: Putting Some Emphasis on Invasive Pleomorphic Lobular Carcinoma as a Potential Mimic of Urothelial Carcinoma at Metastatic Sites
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Uroplakin II antibody is exclusively specific for urothelial carcinoma.
Nonurothelial carcinoma has not been reported to be immunoreactive for uroplakin II.
In the present study, we hypothesized that breast carcinoma showing apocrine differentiation, such as invasive pleomorphic lobular carcinoma (IPLC) and apocrine carcinoma (AC), stains positive for uroplakin II.
We identified 6 cases of IPLC between 2000 and 2014 by searching a computerized pathological database.
We randomly selected 10 cases of each classic invasive lobular carcinoma (cILC) and AC and five cases of apocrine metaplasia (AM) that coexisted in a surgically resected breast carcinoma specimen.
Immunohistochemistry was performed for uroplakin II, GATA3, CK7, CK20, and other representative markers positive for urothelial carcinoma.
All cases of IPLC, AC, and AM, except those of cILC, showed immunoreactivity for uroplakin II.
Poorly differentiated urothelial carcinoma sometimes shows similar morphology to IPLC with the following immunophenotype: CK7+, CK20−, GATA3+, and uroplakin II+.
In the present study, this immunophenotype was observed in all the cases of IPLC and AC.
Therefore, when studying metastatic, poorly differentiated carcinoma showing the aforementioned immunophenotype, we should consider the possibility of it being IPLC in addition to metastatic urothelial carcinoma.
American Psychological Association (APA)
Tajima, Shogo& Koda, Kenji. 2016. Uroplakin II Expression in Breast Carcinomas Showing Apocrine Differentiation: Putting Some Emphasis on Invasive Pleomorphic Lobular Carcinoma as a Potential Mimic of Urothelial Carcinoma at Metastatic Sites. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103680
Modern Language Association (MLA)
Tajima, Shogo& Koda, Kenji. Uroplakin II Expression in Breast Carcinomas Showing Apocrine Differentiation: Putting Some Emphasis on Invasive Pleomorphic Lobular Carcinoma as a Potential Mimic of Urothelial Carcinoma at Metastatic Sites. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103680
American Medical Association (AMA)
Tajima, Shogo& Koda, Kenji. Uroplakin II Expression in Breast Carcinomas Showing Apocrine Differentiation: Putting Some Emphasis on Invasive Pleomorphic Lobular Carcinoma as a Potential Mimic of Urothelial Carcinoma at Metastatic Sites. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103680