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A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome
Joint Authors
Jabaudon, Matthieu
Constantin, Jean-Michel
Blondonnet, Raiko
Sapin, Vincent
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Acute respiratory distress syndrome (ARDS) is an acute-onset hypoxic condition with radiographic bilateral lung infiltration.
It is characterized by an acute exudative phase combining diffuse alveolar damage and lung edema followed by a later fibroproliferative phase.
Despite an improved understanding of ARDS pathobiology, our ability to predict the development of ARDS and risk-stratify patients with the disease remains limited.
Biomarkers may help to identify patients at the highest risk of developing ARDS, assess response to therapy, predict outcome, and optimize enrollment in clinical trials.
After a short description of ARDS pathobiology, here, we review the scientific evidence that supports the value of various ARDS biomarkers with regard to their major biological roles in ARDS-associated lung injury and/or repair.
Ongoing research aims at identifying and characterizing novel biomarkers, in order to highlight relevant mechanistic explorations of lung injury and repair, and to ultimately develop innovative therapeutic approaches for ARDS patients.
This review will focus on the pathophysiologic, diagnostic, and therapeutic implications of biomarkers in ARDS and on their utility to ultimately improve patient care.
American Psychological Association (APA)
Blondonnet, Raiko& Constantin, Jean-Michel& Sapin, Vincent& Jabaudon, Matthieu. 2016. A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome. Disease Markers،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1103684
Modern Language Association (MLA)
Blondonnet, Raiko…[et al.]. A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome. Disease Markers No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1103684
American Medical Association (AMA)
Blondonnet, Raiko& Constantin, Jean-Michel& Sapin, Vincent& Jabaudon, Matthieu. A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1103684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103684