WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease
Joint Authors
Zhang, Qi
Zhang, Cuiping
Li, Xiaoyu
Yu, Yanan
Liang, Kun
Shan, Xinzhi
Zhao, Kun
Niu, Qinghui
Tian, Zibin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) is mainly characterized by intestinal tissue damage, which is caused by excessive autoimmune responses poorly controlled by corresponding regulatory mechanisms.
WISP1, which belongs to the CCN protein family, is a secreted matricellular protein regulating several inflammatory pathways, such as Wnt/β-catenin pathway, and has been reported in several diseases including cancer.
Here we examined the expression, regulatory mechanisms, and functions of WISP1 in IBD.
WISP1 mRNA and protein expression was upregulated in colonic biopsies and lamina propria mononuclear cells (LPMC) of IBD patients compared with those of healthy controls.
Tumor necrosis factor- (TNF-) α induced WISP1 expression in LPMC from healthy controls.
Consistently, WISP1 mRNA expression was downregulated in colonic biopsies from IBD patients who had achieved clinical remission with infliximab (IFX).
Furthermore, WISP1 expression was also found to be increased in colons from 2,4,6-trinitrobenzenesulfonic acid- (TNBS-) induced mice compared with those from control mice.
Further studies confirmed that administration of rWISP1 could aggravate TNBS-induced colitis in vivo.
Therefore, we concluded that WISP1 is increased in IBD and contributes to the proinflammatory cascades in the gut.
American Psychological Association (APA)
Zhang, Qi& Zhang, Cuiping& Li, Xiaoyu& Yu, Yanan& Liang, Kun& Shan, Xinzhi…[et al.]. 2016. WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease. Disease Markers،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103687
Modern Language Association (MLA)
Zhang, Qi…[et al.]. WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease. Disease Markers No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1103687
American Medical Association (AMA)
Zhang, Qi& Zhang, Cuiping& Li, Xiaoyu& Yu, Yanan& Liang, Kun& Shan, Xinzhi…[et al.]. WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103687