Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer
Joint Authors
Sun, Mingzhong
Song, Jiangxiang
Zhou, Zhongwei
Zhu, Rong
Jin, Hao
Ji, Yuqiao
Lu, Qiang
Ju, Huixiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To compare the clinical value of serum microRNA21 (miR21) and other tumor markers in early diagnosis of non-small cell lung cancer (NSCLC).
Methods.
Serums carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), neuron-specific enolase (NSE), and miR21 were detected in 50 NSCLC cases and 60 healthy control individuals.
Results.
Average serums miR21, CEA, NSE, and CYFRA21-1 levels were significantly higher in the case group than in control group (P<0.01).
Analysis of areas under the receiver operating characteristic (ROC) curve (AUC) revealed that CEA had the highest diagnostic efficiency for NSCLC.
Serums miR21 and CYFRA21-1 levels were significantly lower at TNM stages I-II than stages III-IV (P<0.05).
Further, logistic multivariate regression analysis showed that the incidence of early NSCLC (TNM stages I-II) was correlated with serums CYFRA21-1 (OR = 1.076) and miR21 (OR = 2.473) levels (P<0.05).
By AUC analysis, miR21 had the highest diagnostic efficiency for early NSCLC, and single or combined detection of serums CYFRA21-1 and miR21 levels showed improved diagnostic efficiency for joint detection of both markers.
Conclusions.
Serum miR21 could serve as an important marker for auxiliary diagnosis of early NSCLC, while joint detection of serums miR21 and CYFRA21-1 levels could improve diagnostic efficiency.
American Psychological Association (APA)
Sun, Mingzhong& Song, Jiangxiang& Zhou, Zhongwei& Zhu, Rong& Jin, Hao& Ji, Yuqiao…[et al.]. 2016. Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103695
Modern Language Association (MLA)
Sun, Mingzhong…[et al.]. Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103695
American Medical Association (AMA)
Sun, Mingzhong& Song, Jiangxiang& Zhou, Zhongwei& Zhu, Rong& Jin, Hao& Ji, Yuqiao…[et al.]. Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103695