Quantitative and Qualitative Analysis of Circulating Cell-Free DNA Can Be Used as an Adjuvant Tool for Prostate Cancer Screening: A Meta-Analysis
Joint Authors
Yuan, Chun-Hui
Wang, Fu-Bing
Yin, Chang-Qing
Luo, Changliang
Hu, Wei
Ding, Xu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
As part of “liquid biopsy,” lots of literature indicated the potential diagnostic value of circulating cell-free DNA (cfDNA) in the management of prostate cancer (PCa).
However, the literature on the accuracy of cfDNA detection in PCa has been inconsistent.
Hence, we performed this meta-analysis to assess the diagnostic value of cfDNA in PCa.
A total of 19 articles were included in this analysis according to the inclusion and exclusion criteria.
We then investigated two main subgroups in this meta-analysis, including qualitative analysis of abnormal level of cfDNA and qualitative analysis of single-gene methylation alterations.
Overall, the results of quantitative analysis showed sensitivity of 0.73 (95% CI, 0.62–0.82) and specificity of 0.80 (95% CI, 0.70–0.87), with an area under the curve (AUC) of 0.83 (95% CI, 0.80–0.86).
For qualitative assessment, the values were 0.34 (95% CI, 0.22–0.48), 0.99 (95% CI, 0.97–1.00), and 0.91 (95% CI, 0.88–0.93), respectively.
Our results suggest the pooled specificity of each subgroup is much higher than the specificity of prostate-specific antigen (PSA).
However, they are not recommended for PCa screening alone, because their sensitivities are not higher than the conventional serum biomarkers PSA.
We conclude that analysis of cfDNA can be used as an adjuvant tool for PCa screening.
American Psychological Association (APA)
Yin, Chang-Qing& Luo, Changliang& Hu, Wei& Ding, Xu& Yuan, Chun-Hui& Wang, Fu-Bing. 2016. Quantitative and Qualitative Analysis of Circulating Cell-Free DNA Can Be Used as an Adjuvant Tool for Prostate Cancer Screening: A Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103696
Modern Language Association (MLA)
Yin, Chang-Qing…[et al.]. Quantitative and Qualitative Analysis of Circulating Cell-Free DNA Can Be Used as an Adjuvant Tool for Prostate Cancer Screening: A Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103696
American Medical Association (AMA)
Yin, Chang-Qing& Luo, Changliang& Hu, Wei& Ding, Xu& Yuan, Chun-Hui& Wang, Fu-Bing. Quantitative and Qualitative Analysis of Circulating Cell-Free DNA Can Be Used as an Adjuvant Tool for Prostate Cancer Screening: A Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103696