![](/images/graphics-bg.png)
Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease
Joint Authors
Luo, Liyun
Chen, Bairong
Li, Songbiao
Wei, Xiaoliang
Liu, Tianmin
Huang, Yin
Lin, Xiufang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD).
The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD.
Materials and Methods.
Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n=29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n=17), or ST elevation MI (STEMI) (n=14) and 20 non-CAD subjects were assessed by real-time polymerase chain reaction (qRT-PCR), and associations of miR-10a levels with risk factors of CAD and its severity were analyzed.
Results.
The qRT-PCR results showed that plasma miR-10a levels were decreased in CAD patients, and CAD with high SYNTAX scores or STEMI was significantly associated with lower miR-10a levels.
Conclusions.
Lower plasma miR-10a levels were negatively associated with the presence as well as severity of CAD, and plasma miR-10a can act as a potential biomarker for estimating the presence and severity of CAD.
American Psychological Association (APA)
Luo, Liyun& Chen, Bairong& Li, Songbiao& Wei, Xiaoliang& Liu, Tianmin& Huang, Yin…[et al.]. 2016. Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease. Disease Markers،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103697
Modern Language Association (MLA)
Luo, Liyun…[et al.]. Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease. Disease Markers No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103697
American Medical Association (AMA)
Luo, Liyun& Chen, Bairong& Li, Songbiao& Wei, Xiaoliang& Liu, Tianmin& Huang, Yin…[et al.]. Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103697