Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects

Abstract EN

Context.

Hypovitaminosis D frequently occurs in early life and increases with age.

Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure.

Objectives.

To assess the vitamin D status and the impact of hypovitaminosis D on circulating NT-proBNP levels in young patients with congenital heart defects (CHD).

Design and Patients.

This cross-sectional study included the assessment of serum 25-hydroxyvitamin D (25OHD), parathyroid function markers, and NT-proBNP levels in a series of 230 young in-patients (117 females, 113 males; 6.4 (4.0–9.1) years (median, interquartile range)) with CHD.

Results.

Serum 25OHD levels <20 ng/mL were detected in 55.3% of patients.

Optimal 25OHD levels (>30 ng/mL) occurred in 25% of patients.

Serum 25OHD levels inversely correlated with age (r=-0.169, P=0.013) and height standard deviation score (r=-0.269, P=0.001).

After correction for age, 25OHD negatively correlated with serum PTH levels (β=-0.200, P=0.002).

PTH levels above the upper quartile (44 pg/mL) occurred in 32% of hypovitaminosis D patients.

Serum NT-proBNP levels were not correlated with 25OHD and PTH levels.

Conclusions.

Half of the young CHD patients were diagnosed with 25OHD deficiency and a third of hypovitaminosis D patients experienced hyperparathyroidism.

Nonetheless, serum NT-proBNP levels were not associated with hypovitaminosis D as well as hyperparathyroidism.