![](/images/graphics-bg.png)
Plasma Cathepsin S and Cathepsin SCystatin C Ratios Are Potential Biomarkers for COPD
Joint Authors
Chubachi, Shotaro
Nakajima, Takahiro
Nakamura, Hidetoshi
Owen, Caroline A.
Yoshida, Shuichi
Tsuduki, Keishi
Shirahata, Toru
Mashimo, Shuko
Nakamura, Miho
Takahashi, Saeko
Minematsu, Naoto
Tateno, Hiroki
Fujishima, Seitaro
Asano, Koichiro
Celli, Bartolome R.
Betsuyaku, Tomoko
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
This study aimed to examine whether plasma levels of cathepsin S or its inhibitor, cystatin C, may serve as biomarkers for COPD.
Patients and Methods.
We measured anthropometrics and performed pulmonary function tests and chest CT scans on 94 patients with COPD and 31 subjects with productive cough but no airflow obstruction (“at risk”; AR).
In these subjects and in 52 healthy nonsmokers (NS) and 66 healthy smokers (HS) we measured plasma concentrations of cathepsin S and cystatin C using an ELISA.
Data were analyzed using simple and logistic regression and receiver operating characteristic analyses.
Results.
Cathepsin S and cystatin C plasma levels were significantly higher in the COPD and AR groups than in the NS and HS groups (p<0.01).
Among the COPD patients and AR subjects, plasma cathepsin S levels and cathepsin S/cystatin C ratios, but not cystatin C levels, were negatively related to severe airflow limitation (% FEV1 predicted < 50%; p=0.005) and severe emphysema as assessed by low attenuation area (LAA) score on chest CT scans (LAA ≥ 8.0; p=0.001).
Conclusion.
Plasma cathepsin S and cathepsin S/cystatin C ratios may serve as potential biomarkers for COPD.
American Psychological Association (APA)
Nakajima, Takahiro& Nakamura, Hidetoshi& Owen, Caroline A.& Yoshida, Shuichi& Tsuduki, Keishi& Chubachi, Shotaro…[et al.]. 2016. Plasma Cathepsin S and Cathepsin SCystatin C Ratios Are Potential Biomarkers for COPD. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103700
Modern Language Association (MLA)
Nakajima, Takahiro…[et al.]. Plasma Cathepsin S and Cathepsin SCystatin C Ratios Are Potential Biomarkers for COPD. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103700
American Medical Association (AMA)
Nakajima, Takahiro& Nakamura, Hidetoshi& Owen, Caroline A.& Yoshida, Shuichi& Tsuduki, Keishi& Chubachi, Shotaro…[et al.]. Plasma Cathepsin S and Cathepsin SCystatin C Ratios Are Potential Biomarkers for COPD. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103700