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Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor
Joint Authors
Kim, Hye Min
Lee, Yu Kyung
Koo, Ja Seung
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT).
Methods.
Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed.
We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFR α/β, and NG2) and analyzed the results according to clinicopathologic parameters.
Results.
Expression of PDGFRα and PDGFRβ in the stromal component increased with increasing histologic grade of PT (p=0.003 and p=0.034, resp.).
Among clinicopathologic parameters, only expression of FAPα in stroma was associated with distant metastasis (p=0.002).
In univariate analysis, stromal expression of PDGFRα was associated with shorter overall survival (p=0.002).
In Cox multivariate analysis, stromal overgrowth and PDGFRα stromal positivity were associated with shorter overall survival (p=0.006 and p=0.050, resp.).
Furthermore, expression of PDGFRβ in stroma was associated with shorter overall survival in patients with malignant PT (p=0.041).
Conclusion.
Stromal expression of PDGFRα and PDGFRβ increased with increasing histologic grade of PT.
In addition, PDGFR stromal positivity was associated with shorter overall survival.
These results suggest that CAFs are associated with breast PT progression.
American Psychological Association (APA)
Kim, Hye Min& Lee, Yu Kyung& Koo, Ja Seung. 2016. Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor. Disease Markers،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103703
Modern Language Association (MLA)
Kim, Hye Min…[et al.]. Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor. Disease Markers No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103703
American Medical Association (AMA)
Kim, Hye Min& Lee, Yu Kyung& Koo, Ja Seung. Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103703