Discovery of Novel Biomarkers for Alzheimer’s Disease from Blood
Joint Authors
Long, Jintao
Pan, Genhua
Belshaw, Robert
Li, Xinzhong
Ifeachor, Emmanuel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Blood-based biomarkers for Alzheimer’s disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling.
However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis.
In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers.
We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain.
Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (>87%), specificity (>91%), and accuracy (>89%).
American Psychological Association (APA)
Long, Jintao& Pan, Genhua& Ifeachor, Emmanuel& Belshaw, Robert& Li, Xinzhong. 2016. Discovery of Novel Biomarkers for Alzheimer’s Disease from Blood. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103704
Modern Language Association (MLA)
Long, Jintao…[et al.]. Discovery of Novel Biomarkers for Alzheimer’s Disease from Blood. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103704
American Medical Association (AMA)
Long, Jintao& Pan, Genhua& Ifeachor, Emmanuel& Belshaw, Robert& Li, Xinzhong. Discovery of Novel Biomarkers for Alzheimer’s Disease from Blood. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103704
