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From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers
Joint Authors
Căruntu, Constantin
Căruntu, Ana
Greabu, Maria
Calenic, Bogdan
Voiculescu, Vlad
Ghita, Mihaela
Lupu, Mihai
Moraru, Liliana
Voiculescu, Suzana
Ion, Alexandra
Ishkitiev, Nikolay
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Squamous cells carcinoma (SCC) is the second most frequent of the keratinocyte-derived malignancies after basal cell carcinoma and is associated with a significant psychosocial and economic burden for both the patient himself and society.
Reported risk factors for the malignant transformation of keratinocytes and development of SCC include ultraviolet light exposure, followed by chronic scarring and inflammation, exposure to chemical compounds (arsenic, insecticides, and pesticides), and immune-suppression.
Despite various available treatment methods and recent advances in noninvasive or minimal invasive diagnostic techniques, the risk recurrence and metastasis are far from being negligible, even in patients with negative histological margins and lymph nodes.
Analyzing normal, dysplastic, and malignant keratinocyte proteome holds special promise for novel biomarker discovery in SCC that could be used in the future for early detection, risk assessment, tumor monitoring, and development of targeted therapeutic strategies.
American Psychological Association (APA)
Voiculescu, Vlad& Calenic, Bogdan& Ghita, Mihaela& Lupu, Mihai& Căruntu, Ana& Moraru, Liliana…[et al.]. 2016. From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers. Disease Markers،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1103706
Modern Language Association (MLA)
Voiculescu, Vlad…[et al.]. From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers. Disease Markers No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1103706
American Medical Association (AMA)
Voiculescu, Vlad& Calenic, Bogdan& Ghita, Mihaela& Lupu, Mihai& Căruntu, Ana& Moraru, Liliana…[et al.]. From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1103706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103706