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Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis
Joint Authors
De Paoli, Marine
Gogalic, Selma
Sauer, Ursula
Preininger, Claudia
Pandha, Hardev
Simpson, Guy
Horvath, Andras
Marquette, Christophe A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Nonmuscle invasive bladder cancer (BCa) has a high recurrence rate requiring lifelong surveillance.
Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of recurrent bladder cancer.
However, no single marker can achieve the required accuracy.
The purpose of this study was to select a multiparameter panel, comprising urinary biomarkers and clinical parameters, for BCa recurrence diagnosis.
Experimental Design.
Candidate biomarkers were measured in urine samples of BCa patients with recurrence and BCa patients without recurrence.
A multiplatform strategy was used for marker quantification comprising a multiplexed microarray and an automated platform for ELISA analysis.
A multivariate statistical analysis combined the results from both platforms with the collected clinical data.
Results.
The best performing combination of biomarkers and clinical parameters achieved an AUC value of 0.91, showing better performance than individual parameters.
This panel comprises six biomarkers (cadherin-1, IL-8, ErbB2, IL-6, EN2, and VEGF-A) and three clinical parameters (number of past recurrences, number of BCG therapies, and stage at time of diagnosis).
Conclusions.
The multiparameter panel could be a useful noninvasive tool for BCa surveillance and potentially impact the clinical management of this disease.
Validation of results in an independent cohort is warranted.
American Psychological Association (APA)
De Paoli, Marine& Gogalic, Selma& Sauer, Ursula& Preininger, Claudia& Pandha, Hardev& Simpson, Guy…[et al.]. 2016. Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103709
Modern Language Association (MLA)
De Paoli, Marine…[et al.]. Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103709
American Medical Association (AMA)
De Paoli, Marine& Gogalic, Selma& Sauer, Ursula& Preininger, Claudia& Pandha, Hardev& Simpson, Guy…[et al.]. Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103709