RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population
Joint Authors
Mutuiri, Shem P. M.
Kutima, Helen L.
Mwapagha, Lamech M.
Munyao, James K.
Nyamache, Anthony Kebira
Wanjiru, Irene
Khamadi, Samoel A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Previous studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, -403G/A and -28C/G, are associated with a slower rate of decline in CD4+ T cell count.
In addition, as a ligand of the major HIV coreceptor CCR5, it is known to block HIV-CCR5 interactions in the course of the HIV infection cycle.
This study was carried out with the aim of determining the occurrence of single nucleotide polymorphisms (SNPs) -403G > A and -28C > G in the promoter region of RANTES, in a subset of the Kenyan population.
Genomic DNA was extracted from peripheral blood monocular cells and used to amplify the RANTES gene region.
Restriction fragment length polymorphism was used to determine the genotypes of the RANTES gene.
Out of 100 HIV infected individuals, 19% had G1 genotypes (403G/G, 28C/G), 30% (403A/A, 28C/C), and 50% (403G/A, 28C/C), while in healthy blood donors 13% had G4 (403G/A, 28C/C) genotypes, 22% (403A/A, 28C/C), and 54% (403G/A, 28C/C).
HIV negative blood donors (54%) had higher risk of alteration to risk of HIV transmission compared to those who were HIV infected (50%).
However, the risk to transmission and distribution differences was not significant (P=0.092).
The study showed that RANTES polymorphisms -403 and -28 alleles do exist in the Kenyan population.
American Psychological Association (APA)
Mutuiri, Shem P. M.& Kutima, Helen L.& Mwapagha, Lamech M.& Munyao, James K.& Nyamache, Anthony Kebira& Wanjiru, Irene…[et al.]. 2016. RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103712
Modern Language Association (MLA)
Mutuiri, Shem P. M.…[et al.]. RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103712
American Medical Association (AMA)
Mutuiri, Shem P. M.& Kutima, Helen L.& Mwapagha, Lamech M.& Munyao, James K.& Nyamache, Anthony Kebira& Wanjiru, Irene…[et al.]. RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103712