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Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis
Joint Authors
Hamai, Kosuke
Iwamoto, Hiroshi
Ishikawa, Nobuhisa
Horimasu, Yasushi
Masuda, Takeshi
Miyamoto, Shintaro
Nakashima, Taku
Fujitaka, Kazunori
Hamada, Hironobu
Hattori, Noboru
Kohno, Nobuoki
Ohshimo, Shinichiro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Recent reports indicate that matrix metalloproteinase-7 (MMP-7) and CC-chemokine ligand 18 (CCL18) are potential disease markers of idiopathic pulmonary fibrosis (IPF).
The objective of this study was to perform direct comparisons of these two biomarkers with three well-investigated serum markers of IPF, Krebs von den Lungen-6 (KL-6), surfactant protein-A (SP-A), and SP-D.
Methods.
The serum levels of MMP-7, CCL18, KL-6, SP-A, and SP-D were evaluated in 65 patients with IPF, 31 patients with bacterial pneumonia, and 101 healthy controls.
The prognostic performance of these five biomarkers was evaluated in patients with IPF.
Results.
The serum levels of MMP-7, KL-6, and SP-D in patients with IPF were significantly elevated compared to those in patients with bacterial pneumonia and in the healthy controls.
Multivariate survival analysis showed that serum MMP-7 and KL-6 levels were independent predictors in IPF patients.
Moreover, elevated levels of both KL-6 and MMP-7 were associated with poorer survival rates in IPF patients, and the combination of both markers provided the best risk discrimination using the C statistic.
Conclusions.
The present results indicated that MMP-7 and KL-6 were promising prognostic markers of IPF, and the combination of the two markers might improve survival prediction in patients with IPF.
American Psychological Association (APA)
Hamai, Kosuke& Iwamoto, Hiroshi& Ishikawa, Nobuhisa& Horimasu, Yasushi& Masuda, Takeshi& Miyamoto, Shintaro…[et al.]. 2016. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103713
Modern Language Association (MLA)
Hamai, Kosuke…[et al.]. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103713
American Medical Association (AMA)
Hamai, Kosuke& Iwamoto, Hiroshi& Ishikawa, Nobuhisa& Horimasu, Yasushi& Masuda, Takeshi& Miyamoto, Shintaro…[et al.]. Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103713