Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis

Joint Authors

Javed, Fawad
Akram, Zohaib
Abduljabbar, Tariq
Abu Hassan, Mohamed Ibrahim
Vohra, Fahim

Source

Disease Markers

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-26

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms.

Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β.

Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals.

Eleven studies were included.

Three studies showed comparable levels of leptin among obese and nonobese patients with CP.

Four studies reported comparable levels of interleukin- (IL-) 6 and resistin whereas five studies reported comparable levels of adiponectin.

Two studies reported similar levels of CRP in patients with periodontitis with and without obesity.

One study showed higher levels of tumor necrosis factor-alpha in obese patients with CP.

One study showed higher levels of IL-1β and IL-8 in obese patients with CP.

The level of localized periodontal inflammation may have a greater influence on the GCF proinflammatory biomarker levels as compared to systemic obesity.

Whether patients having chronic periodontitis with obesity have elevated proinflammatory GCF biomarkers levels compared to nonobese individuals remains debatable.

American Psychological Association (APA)

Akram, Zohaib& Abduljabbar, Tariq& Abu Hassan, Mohamed Ibrahim& Javed, Fawad& Vohra, Fahim. 2016. Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103714

Modern Language Association (MLA)

Akram, Zohaib…[et al.]. Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103714

American Medical Association (AMA)

Akram, Zohaib& Abduljabbar, Tariq& Abu Hassan, Mohamed Ibrahim& Javed, Fawad& Vohra, Fahim. Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103714

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1103714