The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study
Joint Authors
Daniil, Zoe
Aggelou, Kalliopi
Siapati, Elena Konstantina
Gerogianni, Irini
Ntanos, Ioannis
Simantirakis, Emmanouel
Mollaki, Vassiliki
Gourgoulianis, K. I.
Zintzaras, Elias
Vassilopoulos, G.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Tuberculosis (TB) is a major disease worldwide, caused by Mycobacterium tuberculosis (MTB) infection.
The Toll-Like Receptor (TLR) pathway plays a crucial role in the recognition of MTB.
Aim.
The present study aimed to investigate the involvement of myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms in TB.
Materials and Methods.
A total of 103 TB cases and 92 control subjects were genotyped for the MYD88 -938C>A (rs4988453) and 1944C>G (rs4988457) polymorphisms.
Results.
The MYD88 -938CA and -938AA genotypes were associated with an increased risk for tuberculosis with odds ratio (OR) of 5.71 (95% confidence intervals [CIs] 2.89–11.28, p=0.01).
Conclusions.
The MYD88 -938C>A genetic polymorphism is associated with increased susceptibility to TB and may serve as a marker to screen individuals who are at risk.
American Psychological Association (APA)
Aggelou, Kalliopi& Siapati, Elena Konstantina& Gerogianni, Irini& Daniil, Zoe& Gourgoulianis, K. I.& Ntanos, Ioannis…[et al.]. 2016. The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study. Disease Markers،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103718
Modern Language Association (MLA)
Aggelou, Kalliopi…[et al.]. The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study. Disease Markers No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103718
American Medical Association (AMA)
Aggelou, Kalliopi& Siapati, Elena Konstantina& Gerogianni, Irini& Daniil, Zoe& Gourgoulianis, K. I.& Ntanos, Ioannis…[et al.]. The -938C>A Polymorphism in MYD88 Is Associated with Susceptibility to Tuberculosis: A Pilot Study. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103718
