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Autoantibody Response to ZRF1 and KRR1 SEREX Antigens in Patients with Breast Tumors of Different Histological Types and Grades
Joint Authors
Dyachenko, Lada
Havrysh, Kristina
Lytovchenko, Anita
Dosenko, Irina
Antoniuk, Stepan
Filonenko, Valeriy
Kiyamova, Ramziya
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To investigate a frequency of antibody response to SEREX-identified medullary breast carcinoma autoantigens ZRF1 and KRR1 in sera of breast cancer patients taking into account clinical and molecular characteristics of tumors for opening of new perspectives in creation of minimally invasive immunological tests for cancer diagnostics.
Methods.
Enzyme-linked immunosorbent assay and bioinformatics analysis.
Results.
Increased frequency of antibody response was found in sera of breast cancer patients to ZRF and KRR1 antigens.
The antibody response to these antigens was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors.
Moreover, more frequent antibody response to ZRF antigen was found in sera of patients with less aggressive tumors.
The sequence analysis of ZRF1 antigen SEREX clones obtained from cDNA libraries of different tumors demonstrates that they encode different protein isoforms.
Conclusion.
Tumor-associated antigens KRR1 and ZRF1 and their cognate autoantibodies could be considered as potential molecular markers of breast cancer which need to be further investigated.
American Psychological Association (APA)
Dyachenko, Lada& Havrysh, Kristina& Lytovchenko, Anita& Dosenko, Irina& Antoniuk, Stepan& Filonenko, Valeriy…[et al.]. 2016. Autoantibody Response to ZRF1 and KRR1 SEREX Antigens in Patients with Breast Tumors of Different Histological Types and Grades. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103719
Modern Language Association (MLA)
Dyachenko, Lada…[et al.]. Autoantibody Response to ZRF1 and KRR1 SEREX Antigens in Patients with Breast Tumors of Different Histological Types and Grades. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103719
American Medical Association (AMA)
Dyachenko, Lada& Havrysh, Kristina& Lytovchenko, Anita& Dosenko, Irina& Antoniuk, Stepan& Filonenko, Valeriy…[et al.]. Autoantibody Response to ZRF1 and KRR1 SEREX Antigens in Patients with Breast Tumors of Different Histological Types and Grades. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103719