Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions
Joint Authors
Ruan, Qiurong
Yang, Shouhua
Cheng, Henghui
Qu, Zhiling
Zhou, Sheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
DOG1 has proven to be a useful marker of gastrointestinal stromal tumors (GISTs).
Recently, DOG1 expression has also been reported in some non-GIST malignant tumors, but the details related to DOG1 expression in breast tissue remain unclear.
The aim of this study was to detect the expression of DOG1 in the human breast and to evaluate the feasibility of using DOG1 to discriminate between invasive breast carcinoma and noninvasive breast lesions.
Methods and Results.
A total of 210 cases, including both invasive and noninvasive breast lesions, were collected to assess DOG1 expression immunohistochemically.
DOG1 expression was consistently positive in breast myoepithelial cells (MECs), which was similar to the results obtained for three other MEC markers: calponin, smooth muscle myosin heavy chain (SMMHC), and P63 ( P > 0.05 in all).
Importantly, DOG1 was useful in discriminating invasive breast carcinoma from noninvasive breast lesions ( P < 0.05 ).
Conclusions.
DOG1 is a useful marker of breast MECs, and adding DOG1 to the MEC identification panel will provide more sophisticated information when diagnosing uncertain cases in the breast.
American Psychological Association (APA)
Cheng, Henghui& Yang, Shouhua& Qu, Zhiling& Zhou, Sheng& Ruan, Qiurong. 2016. Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103728
Modern Language Association (MLA)
Cheng, Henghui…[et al.]. Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103728
American Medical Association (AMA)
Cheng, Henghui& Yang, Shouhua& Qu, Zhiling& Zhou, Sheng& Ruan, Qiurong. Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103728