Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy
Joint Authors
Gunbey, Hediye Pınar
Ercan, Karabekir
Arslan, Halil
Bilir, Erhan
Zan, Elcin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
The objective is to compare lateralizing ability of three quantitative MR (qMRI) modalities to depict changes of hippocampal architecture with clinical entities in temporal lobe epilepsy.
Methods.
We evaluated 14 patients with clinical and EEG proven diagnosis of unilateral TLE and 15 healthy volunteers.
T1-weighted 3D dataset for volumetry, single-voxel 1H MR spectroscopy (MRS), and diffusion tensor imaging (DTI) were performed for bilateral hippocampi of all subjects.
Results.
Individual volumetric measurements provided accurate lateralization in 85% of the patients, spectroscopy in 57%, and DTI in 57%.
Higher lateralization ratios were acquired combining volumetry-spectroscopy (85%), spectroscopy-DTI (85%), and volumetry-DTI (100%).
Significantly decreased NAA/(Cho+Cr) ratios ( p = 0.002 ) and increased FA ( p = 0.001 ) values were obtained in ipsilateral to epileptogenic hippocampus.
Duration of epilepsy and FA values showed a significant negative correlation ( p = 0.016 , r = - 0.847 ).
The history of febrile convulsion associated with ipsilateral increased ADC values ( p = 0.015 , r = 0.851 ) and reduced NAA/(Cho+Cr) ratios ( p = 0.047 , r = - 761 ).
Conclusion.
Volumetry, MRS, and DTI studies provide complementary information of hippocampal pathology.
For lateralization of epileptogenic focus and preoperative examination, volumetry-DTI combination may be indicative of diagnostic accuracy.
American Psychological Association (APA)
Ercan, Karabekir& Gunbey, Hediye Pınar& Bilir, Erhan& Zan, Elcin& Arslan, Halil. 2016. Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103734
Modern Language Association (MLA)
Ercan, Karabekir…[et al.]. Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103734
American Medical Association (AMA)
Ercan, Karabekir& Gunbey, Hediye Pınar& Bilir, Erhan& Zan, Elcin& Arslan, Halil. Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103734