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Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study
Joint Authors
Gursu, Meltem
Dane, Banu
Batmaz, Gonca
Ozturk, Savas
Ates, Seda
Karadag, Serhat
Yildirim, Zeynep Kayaoglu
Bademler, Neslihan
Kilic, Elif
Sumnu, Gulay
Ozel, Aysegul
Sumnu, Abdullah
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction.
Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders.
sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease.
In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group.
Materials and Methods.
The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women.
The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit.
Results.
Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group.
sTWEAK levels were significantly lower in preeclamptic patients (332 ± 144 pg/mL) than in control subjects (412 ± 166 pg/mL) ( p = 0.04 ).
Discussion.
Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women.
There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.
American Psychological Association (APA)
Yildirim, Zeynep Kayaoglu& Sumnu, Abdullah& Bademler, Neslihan& Kilic, Elif& Sumnu, Gulay& Karadag, Serhat…[et al.]. 2016. Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study. Disease Markers،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103735
Modern Language Association (MLA)
Yildirim, Zeynep Kayaoglu…[et al.]. Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study. Disease Markers No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103735
American Medical Association (AMA)
Yildirim, Zeynep Kayaoglu& Sumnu, Abdullah& Bademler, Neslihan& Kilic, Elif& Sumnu, Gulay& Karadag, Serhat…[et al.]. Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103735