The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer
Joint Authors
Li, Xuqi
Wang, Shufeng
Qiu, Guanglin
Wei, Chao
Che, Xiangming
He, Shicai
Lu, Jing
Pang, Ke
Fan, Lin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators.
However, the relationship between SIRT1 and autophagy in GC has not been defined.
Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients.
Methods.
Transmission electron microscopy (TEM) was performed to examine the autophagy in GC patients.
Immunohistochemistry was used to examine the expression of SIRT1, Beclin-1 in GC, and adjacent nonneoplastic mucosa.
Results.
In 7 out of 8 GC patients’ samples examined by TEM, more autophagic vesicles were observed in GC tissues compared to adjacent nonneoplastic mucosa tissue.
A positive correlation between SIRT1 and Beclin-1 expression was observed.
Furthermore, Beclin-1 or SIRT1 expression alone or their combined expression were significantly correlated with advanced clinicopathological parameters.
High Beclin-1 and SIRT1 expression alone and their combined high expression predicted shorter overall survival and relapse-free survival.
Both high Beclin-1 and SIRT1 expressions were independent prognostic factors for poor survival of GC.
Conclusions.
Based on our results we can conclude that SIRT1 and Beclin-1 expression alone or in combination can be used as prognostic indicator and may represent new therapeutic targets in GC.
American Psychological Association (APA)
Qiu, Guanglin& Li, Xuqi& Wei, Chao& Che, Xiangming& He, Shicai& Lu, Jing…[et al.]. 2016. The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103744
Modern Language Association (MLA)
Qiu, Guanglin…[et al.]. The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer. Disease Markers No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1103744
American Medical Association (AMA)
Qiu, Guanglin& Li, Xuqi& Wei, Chao& Che, Xiangming& He, Shicai& Lu, Jing…[et al.]. The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103744