Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma
Joint Authors
Wang, Lei
Zhang, Yu
Gao, Yu
Fan, Yang
Chen, Luyao
Liu, Kan
Meng, Qingyu
Zhao, Chaofei
Ma, Xin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metastatic renal cell carcinoma (RCC) presents a poor prognosis and an unpredictable course.
To date, no validated biomarkers can predict the outcome of RCC.
Ongoing efforts are conducted to identify the molecular markers of RCC progression, as well as the targets for novel therapeutic approaches.
RET is a tyrosine kinase receptor which has been investigated as a possible target in other cancers because it is involved in oncogenic activation.
To evaluate the predictive and prognostic functions of RET in ccRCC, a tissue microarray study was conducted on 273 ccRCC patients.
Results showed that both RET cytoplasmic and nuclear expression were independently associated with PFS and OS, and the combined RET cytoplasmic and nuclear statuses demonstrated that the ratio of high nuclear RET and cytoplasmic RET was the strongest predictor of both PFS and OS.
The high cytoplasmic RET expression retained its independent poor prognostic value in targeted drug treated patients.
The RET nuclear expression was associated with distant metastasis.
Moreover, the RET nuclear expression was an independent predictor of ccRCC postoperative metastasis.
In conclusion, RET may be useful in prognostication and can be used at initial diagnosis to identify patients with high potential to develop metastasis.
American Psychological Association (APA)
Wang, Lei& Zhang, Yu& Gao, Yu& Fan, Yang& Chen, Luyao& Liu, Kan…[et al.]. 2016. Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103746
Modern Language Association (MLA)
Wang, Lei…[et al.]. Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103746
American Medical Association (AMA)
Wang, Lei& Zhang, Yu& Gao, Yu& Fan, Yang& Chen, Luyao& Liu, Kan…[et al.]. Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103746