Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I
Joint Authors
Assaf, Hanan A.
Abdel-Maged, Wafaa M.
Elsadek, Bakheet E. M.
Hassan, Mohammed H.
Adly, Mohamed A.
Ali, Soher A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation.
Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands.
Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars.
The current study aimed to assess and correlate serum levels of IGF-I and survivin in patients with active acne vulgaris and postinflammatory acne scars and to evaluate their lesional expressions in comparison to healthy controls.
Serum IGF-I and survivin were estimated using commercially available ELISA kits and their tissues expressions were investigated using Western blotting.
Our findings suggest that IGF-I and survivin could play potential roles in the pathogenesis of active acne vulgaris and more importantly in postinflammatory acne scars with significant positive correlation coefficient between serum levels of IGF-I and survivin which support IGF-I-/PI3K-/AKT-mediated downregulation of nuclear expression of FoxO transcription factors resulting in enhanced survivin expression.
American Psychological Association (APA)
Assaf, Hanan A.& Abdel-Maged, Wafaa M.& Elsadek, Bakheet E. M.& Hassan, Mohammed H.& Adly, Mohamed A.& Ali, Soher A.. 2016. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103750
Modern Language Association (MLA)
Assaf, Hanan A.…[et al.]. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103750
American Medical Association (AMA)
Assaf, Hanan A.& Abdel-Maged, Wafaa M.& Elsadek, Bakheet E. M.& Hassan, Mohammed H.& Adly, Mohamed A.& Ali, Soher A.. Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103750