Urinary APE1Ref-1: A Potential Bladder Cancer Biomarker
Joint Authors
Shin, Ju-Hyun
Na, Yong-Gil
Lim, Jae-Sung
Choi, Sunga
Lee, Yu Ran
Joo, Hee Kyoung
Song, Ki Hak
Chang, Seok Jong
Jeon, Byeong Hwa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bladder cancer (BCa) is one of the most common urothelial cancers with still noticeable incidence rate.
Early detection of BCa is highly correlated with successful therapeutic outcomes.
We previously showed that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was expressed at an increased level in the serum of BCa patients when compared to the level in healthy controls.
In this study, we investigated whether urinary APE1/Ref-1 was also elevated in patients with BCa.
In this case-control study, voided urine was collected from 277 subjects including 169 BCa patients and 108 non-BCa controls.
Urinary APE1/Ref-1 level was assessed by enzyme-linked immunosorbent assay (ELISA).
APE1/Ref-1 levels were significantly elevated in BCa patients relative to levels in non-BCa controls and were correlated with tumor grade and stage.
Urinary APE1/Ref-1 levels were also higher in patients with recurrence history of BCa.
The receiver operating characteristics (ROC) curve of APE1/Ref-1 showed an area under the curve of 0.83, indicating the reliability and validity of this biomarker.
The optimal combination of sensitivity and specificity was determined to be 82% and 80% at a cut-off value of 0.376 ng/100 μL for detection of APE1/Ref-1 in urine.
In conclusion, urinary APE1/Ref-1 levels measured from noninvasively obtained body fluids would be clinically applicable for diagnosis of BCa.
American Psychological Association (APA)
Choi, Sunga& Shin, Ju-Hyun& Lee, Yu Ran& Joo, Hee Kyoung& Song, Ki Hak& Na, Yong-Gil…[et al.]. 2016. Urinary APE1Ref-1: A Potential Bladder Cancer Biomarker. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103758
Modern Language Association (MLA)
Choi, Sunga…[et al.]. Urinary APE1Ref-1: A Potential Bladder Cancer Biomarker. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103758
American Medical Association (AMA)
Choi, Sunga& Shin, Ju-Hyun& Lee, Yu Ran& Joo, Hee Kyoung& Song, Ki Hak& Na, Yong-Gil…[et al.]. Urinary APE1Ref-1: A Potential Bladder Cancer Biomarker. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103758