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Measurement of the Red Blood Cell Distribution Width Improves the Risk Prediction in Cardiac Resynchronization Therapy
Joint Authors
Merkely, Béla
Boros, András Mihály
Perge, Péter
Jenei, Zsigmond
Karády, Júlia
Zima, Endre
Molnár, Levente
Becker, Dávid
Gellér, László
Prohászka, Zoltán
Széplaki, Gábor
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objectives.
Increases in red blood cell distribution width (RDW) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) predict the mortality of chronic heart failure patients undergoing cardiac resynchronization therapy (CRT).
It was hypothesized that RDW is independent of and possibly even superior to NT-proBNP from the aspect of long-term mortality prediction.
Design.
The blood counts and serum NT-proBNP levels of 134 patients undergoing CRT were measured.
Multivariable Cox regression models were applied and reclassification analyses were performed.
Results.
After separate adjustment to the basic model of left bundle branch block, beta blocker therapy, and serum creatinine, both the RDW > 13.35% and NT-proBNP > 1975 pg/mL predicted the 5-year mortality ( n = 57 ).
In the final model including all variables, the RDW [HR = 2.49 (1.27–4.86); p = 0.008 ] remained a significant predictor, whereas the NT-proBNP [HR = 1.18 (0.93–3.51); p = 0.07 ] lost its predictive value.
On addition of the RDW measurement, a 64% net reclassification improvement and a 3% integrated discrimination improvement were achieved over the NT-proBNP-adjusted basic model.
Conclusions.
Increased RDW levels accurately predict the long-term mortality of CRT patients independently of NT-proBNP.
Reclassification analysis revealed that the RDW improves the risk stratification and could enhance the optimal patient selection for CRT.
American Psychological Association (APA)
Boros, András Mihály& Perge, Péter& Jenei, Zsigmond& Karády, Júlia& Zima, Endre& Molnár, Levente…[et al.]. 2016. Measurement of the Red Blood Cell Distribution Width Improves the Risk Prediction in Cardiac Resynchronization Therapy. Disease Markers،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103759
Modern Language Association (MLA)
Boros, András Mihály…[et al.]. Measurement of the Red Blood Cell Distribution Width Improves the Risk Prediction in Cardiac Resynchronization Therapy. Disease Markers No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1103759
American Medical Association (AMA)
Boros, András Mihály& Perge, Péter& Jenei, Zsigmond& Karády, Júlia& Zima, Endre& Molnár, Levente…[et al.]. Measurement of the Red Blood Cell Distribution Width Improves the Risk Prediction in Cardiac Resynchronization Therapy. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103759