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Prognostic Value of Perineural Invasion in Esophageal and Esophagogastric Junction Carcinoma: A Meta-Analysis
Joint Authors
Gao, Aiqin
Wang, Linlin
Li, Juan
Li, Hongyu
Han, Yali
Ma, Xiaoxia
Sun, Yuping
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Here we aimed to clarify the prognostic significance of perineural invasion (PNI) in esophageal and esophagogastric junction (EGJ) carcinoma.
Methods.
A comprehensive literature search for relevant reports published up to July 2015 was performed using Pubmed and Embase databases.
The pooled HR and 95% CI for overall survival (OS) and disease-free survival (DFS) were used to assess the prognostic value.
The association of PNI with pathological characteristics was evaluated by OR and 95% CI.
Results.
A total of 13 cohorts were retrieved, covering 2770 patients treated by surgery.
The cumulative analysis revealed a statistical correlation between PNI and poor OS (HR = 1.76, 95% CI: 1.54–2.20, and P<0.00001), as well as poor DFS (HR = 1.96, 95% CI: 1.42–2.71, and P<0.001).
Moreover, analysis of 1475 patients showed improved PNI in T3 + T4 (OR = 0.39, 95% CI: 0.21–0.70, and P=0.002), N+ (OR = 0.52, 95% CI: 0.40–0.69, and P<0.00001), and G3 + G4 (OR = 0.66, 95% CI: 0.48–0.90, and P=0.008) patients compared with T1 + T2, N−, and G1 + G2 ones, respectively.
No significant heterogeneity was found between the studies.
Conclusions.
PNI is an adverse prognostic biomarker in esophageal and EGJ carcinoma.
Moreover, PNI implies advanced T, N stage and poor cell differentiation.
American Psychological Association (APA)
Gao, Aiqin& Wang, Linlin& Li, Juan& Li, Hongyu& Han, Yali& Ma, Xiaoxia…[et al.]. 2016. Prognostic Value of Perineural Invasion in Esophageal and Esophagogastric Junction Carcinoma: A Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103760
Modern Language Association (MLA)
Gao, Aiqin…[et al.]. Prognostic Value of Perineural Invasion in Esophageal and Esophagogastric Junction Carcinoma: A Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103760
American Medical Association (AMA)
Gao, Aiqin& Wang, Linlin& Li, Juan& Li, Hongyu& Han, Yali& Ma, Xiaoxia…[et al.]. Prognostic Value of Perineural Invasion in Esophageal and Esophagogastric Junction Carcinoma: A Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103760
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103760