ACE Gene ID Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus

Abstract EN

Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial.

We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients.

In this study, obesity was defined as a body mass index (BMI) value ≥ 25 kg/m2 and subjects were classified into 4 groups (lean, normal, overweight, and obese).

PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism in T2DM patients.

Metabolic measurements including blood glucose, lipid profile, and blood pressure were obtained.

Frequencies of the ACE genotypes (DD, ID, and II) were not significant among the 4 groups of BMI-defined patients (P=0.679) while ACE II carriers showed higher systolic blood pressure (SBP) and pulse pressure (PP) (all P<0.050).

Hyperglycemia, hypertension, and dyslipidemia in these T2DM patients were found to be significantly associated with BMI.

In conclusion, the relationship of ACE gene I/D polymorphism with obesity is insignificant in Chinese patients with T2DM.

SBP and PP might be higher in the ACE II carriers than in the DD and ID carriers.