KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer
Joint Authors
Zhang, Shu
Huang, Fang
Wang, Yan
Song, Qinjie
Yang, Xiaobing
Wu, Han
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Kinesin family protein 2A (KIF2A), an M-type nonmotile microtubule depolymerase, has attracted attention for its role in carcinogenesis and poor prognoses in various human cancers.
In this study, we aimed to evaluate the expression of KIF2A and its robustness and potential to predict clinical outcomes in gastric cancer (GC) patients.
The messenger RNA (mRNA) expression of KIF2A was determined in 24 pairs of cancerous and adjacent nontumor tissues by real-time polymerase chain reaction.
Immunohistochemistry of KIF2A was performed on a tissue microarray composed of 461 GC and 65 matched adjacent nontumor tissues removed during surgeries and 18 chronic gastritis, 15 intestinal metaplasia, and 37 low-grade and 62 high-grade intraepithelial neoplasias acquired through gastric endoscopic biopsies.
Univariate and multivariate Cox regression models were used to perform survival analyses.
The high KIF2A expression was significantly correlated to histological type, TNM stage, and lymph node metastasis.
A negative correlation was found between KIF2A expression and the 5-year survival rate of GC patients.
In addition, multivariate analysis indicated that KIF2A is an independent prognostic factor in GC.
This study demonstrated the high KIF2A expression might serve as an independent marker for poor prognoses in GC patients.
American Psychological Association (APA)
Zhang, Shu& Huang, Fang& Wang, Yan& Song, Qinjie& Yang, Xiaobing& Wu, Han. 2016. KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103764
Modern Language Association (MLA)
Zhang, Shu…[et al.]. KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103764
American Medical Association (AMA)
Zhang, Shu& Huang, Fang& Wang, Yan& Song, Qinjie& Yang, Xiaobing& Wu, Han. KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103764