Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients
Joint Authors
Kupcinskiene, Kristina
Murnikovaite, Martyna
Varkalaite, Greta
Juzenas, Simonas
Trepenaitis, Darius
Petereit, Ruta
Maleckas, Almantas
Kupcinskas, Juozas
Macas, Andrius
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Obesity is a well-known risk factor for thrombotic complications.
The aim of the present study was to determine the frequency of thrombosis related ABO, F5, MTHFR, and FGG gene polymorphisms in morbidly obese patients and compare them with the group of nonobese individuals.
Methods.
Gene polymorphisms were analyzed in 320 morbidly obese patients (BMI > 40 kg/m2) and 303 control individuals (BMI < 30 kg/m2) of European descent.
ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) SNPs were genotyped by RT-PCR.
Results.
We observed a tendency for MTHFR rs1801133 TT genotype to be linked with morbid obesity when compared to CC genotype; however, the difference did not reach the significant P value (OR 1.84, 95% CI 0.83–4.05, P=0.129).
Overall, the genotypes and alleles of rs505922, rs6427196, rs1801133, and rs6536024 SNPs had similar distribution between morbidly obese and nonobese control individuals.
Distribution of height and weight means among individuals carrying different rs505922, rs6427196, rs1801133, and rs6536024 genotypes did not differ significantly.
Conclusions.
Gene polymorphisms ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects.
American Psychological Association (APA)
Kupcinskiene, Kristina& Murnikovaite, Martyna& Varkalaite, Greta& Juzenas, Simonas& Trepenaitis, Darius& Petereit, Ruta…[et al.]. 2016. Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103772
Modern Language Association (MLA)
Kupcinskiene, Kristina…[et al.]. Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103772
American Medical Association (AMA)
Kupcinskiene, Kristina& Murnikovaite, Martyna& Varkalaite, Greta& Juzenas, Simonas& Trepenaitis, Darius& Petereit, Ruta…[et al.]. Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103772