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Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study
Joint Authors
Kaleta, T.
Stock, A.
Panayotopoulos, D.
Vonend, O.
Kaisers, W.
Fleisch, M. C.
Fehm, T.
Neumann, M. H. D.
Niederacher, D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The purpose of this prospective study was to investigate the predictive value of single prepartum findings combined with serum biomarkers sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) indicating severity of preeclampsia (PE) for occurrence and extent of impaired postpartum kidney function.
Study Design.
In this prospective, single center study 44 PE patients were compared to 39 healthy controls (similar in age and gestational age with singleton pregnancy) evaluated at time of delivery and at 6 months and 12 months postpartum.
p values below 0.05 are considered statistically significant.
Results.
The majority of the PE patients had persistence of proteinuria (>120 mg/L after delivery) 6 months ( p = 0.02 ) and 12 months postpartum ( p < 0.0001 ) compared to controls.
Also reduced GFR (glomerular filtration rate) persisted up to 6 months postpartum in PE patients compared to controls ( p < 0.001 ).
Prepartum sFlt-1 levels indeed correlated with impaired renal function parameters.
Conclusion.
A significant proportion of our PE patients had lower GFR levels and persistent proteinuria up to 12 months postpartum.
Prepartum sFlt-1 is a trend-setting marker for impaired renal function postpartum, but it is not sufficient enough to predict renal impairment after PE.
An evaluation of 24-month follow-up data is scheduled.
American Psychological Association (APA)
Kaleta, T.& Stock, A.& Panayotopoulos, D.& Vonend, O.& Niederacher, D.& Neumann, M. H. D.…[et al.]. 2016. Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103773
Modern Language Association (MLA)
Kaleta, T.…[et al.]. Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103773
American Medical Association (AMA)
Kaleta, T.& Stock, A.& Panayotopoulos, D.& Vonend, O.& Niederacher, D.& Neumann, M. H. D.…[et al.]. Predictors of Impaired Postpartum Renal Function in Women after Preeclampsia: Results of a Prospective Single Center Study. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103773