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Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis
Joint Authors
Huang, Shanshan
Zheng, Jiawei
Huang, Yufang
Song, Li
Yin, Yin
Ou, Danzhen
He, Shangxiang
Chen, Xiong
Ouyang, Xuenong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The small Ca2+-binding protein S100A4 is identified as a metastasis-associated or metastasis-inducing protein in various types of cancer.
The goal of this meta-analysis was to evaluate the relationship between S100A4 expression and clinicopathological characteristics and prognosis of patients with pancreatic cancer.
Methods.
A comprehensive literature search was carried out in the electronic databases PubMed and Chinese CNKI.
Only the studies reporting the correlation between S100A4 expression and clinicopathological characteristics or overall survival (OS) of patients with pancreatic cancer are enrolled.
Extracted data was analyzed using the RevMan 5.3 software to calculate the pooled relative risks (95% confidence interval, CI) for statistical analyses.
Results.
Seven studies including a total of 474 patients were enrolled into this meta-analysis.
Negative expression of S100A4 was significantly associated with higher 3-year OS rate (RR = 3.92, 95% CI = 2.24–6.87, P < 0.0001 ), compared to S100A4-positive cases.
Moreover, negative expression of S100A4 was also related to N0 stage for lymph node metastasis (RR = 2.15, 95% CI = 1.60–2.88, P < 0.0001 ).
However, S100A4 expression was not significantly correlated with histological types and distant metastasis status.
Conclusion.
S100A4 expression represents a potential marker for lymph node metastasis of pancreatic cancer and a potential unfavorable factor for prognosis of patients with this disease.
American Psychological Association (APA)
Huang, Shanshan& Zheng, Jiawei& Huang, Yufang& Song, Li& Yin, Yin& Ou, Danzhen…[et al.]. 2016. Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103780
Modern Language Association (MLA)
Huang, Shanshan…[et al.]. Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103780
American Medical Association (AMA)
Huang, Shanshan& Zheng, Jiawei& Huang, Yufang& Song, Li& Yin, Yin& Ou, Danzhen…[et al.]. Impact of S100A4 Expression on Clinicopathological Characteristics and Prognosis in Pancreatic Cancer: A Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103780