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Immunohistochemical Expression of VEGF and Podoplanin in Uterine Cervical Squamous Intraepithelial Lesions
Joint Authors
Belfort-Mattos, Patrícia Napoli
Focchi, Gustavo Rubino de Azevedo
Ribalta, Julisa Chamorro Lascasas
Megale De Lima, Tatiana
Nogueira Carvalho, Carmen Regina
Kesselring Tso, Fernanda
De Góis Speck, Neila Maria
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
VEGF and podoplanin (PDPN) have been identified as angiogenesis and/or lymphangiogenesis regulators and might be essential to restrict tumor growth, progression, and metastasis.
In the present study, we evaluate the association between the expression of these markers and CIN grade.
Immunohistochemistry was performed in 234 uterine cervical samples using conventional histologic sections or TMA with the monoclonal antibodies to VEGF (C-1 clone) and podoplanin (D2-40 clone).
Positive-staining rates of VEGF in 191 CIN specimens were significantly associated with histological grade (P<0.001).
Negative and/or focal immunostaining for PDPN were more frequent in CIN 3 (P=0.016).
We found that patients with CIN 3 more frequently had strong and more diffuse staining for VEGF and diminished staining for PDPN (P=0.018).
Strong and more diffuse VEGF immunoexpressions in CIN 2 and CIN 3 were detected when compared to CIN 1.
Negative and/or focal PDPN immunoexpression appear to be more frequent in CIN 3.
Moderate to strong VEGF expression may be a tendency among patients with high-grade lesions and diminished PDPN expression.
American Psychological Association (APA)
Belfort-Mattos, Patrícia Napoli& Focchi, Gustavo Rubino de Azevedo& Ribalta, Julisa Chamorro Lascasas& Megale De Lima, Tatiana& Nogueira Carvalho, Carmen Regina& Kesselring Tso, Fernanda…[et al.]. 2016. Immunohistochemical Expression of VEGF and Podoplanin in Uterine Cervical Squamous Intraepithelial Lesions. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103788
Modern Language Association (MLA)
Belfort-Mattos, Patrícia Napoli…[et al.]. Immunohistochemical Expression of VEGF and Podoplanin in Uterine Cervical Squamous Intraepithelial Lesions. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103788
American Medical Association (AMA)
Belfort-Mattos, Patrícia Napoli& Focchi, Gustavo Rubino de Azevedo& Ribalta, Julisa Chamorro Lascasas& Megale De Lima, Tatiana& Nogueira Carvalho, Carmen Regina& Kesselring Tso, Fernanda…[et al.]. Immunohistochemical Expression of VEGF and Podoplanin in Uterine Cervical Squamous Intraepithelial Lesions. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103788