Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of Pathology Linked to G6PD Deficiency and Sulfomucins
Joint Authors
Seneff, Stephanie
Koenig, Gerald
Swanson, Nancy L.
Li, Chen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Osteonecrosis of the jaw (ONJ), a rare side effect of bisphosphonate therapy, is a debilitating disorder with a poorly understood etiology.
FDA’s Adverse Event Reporting System (FAERS) provides the opportunity to investigate this disease.
Our goals were to analyze FAERS data to discover possible relationships between ONJ and specific conditions and drugs and then to consult the scientific literature to deduce biological explanations.
Our methodology revealed a very strong association between gastroesophageal reflux and bisphosphonate-induced ONJ, suggesting acidosis as a key factor.
Overgrowth of acidophilic species, particularly Streptococcus mutans, in the oral microbiome in the context of insufficient acid buffering due to impaired salivary glands maintains the low pH that sustains damage to the mucosa.
Significant associations between ONJ and adrenal insufficiency, vitamin C deficiency, and Sjögren’s syndrome were found.
Glucose 6 phosphate dehydrogenase (G6PD) deficiency can explain much of the pathology.
An inability to maintain vitamin C and other antioxidants in the reduced form leads to vascular oxidative damage and impaired adrenal function.
Thus, pathogen-induced acidosis, hypoxia, and insufficient antioxidant defenses together induce ONJ.
G6PD deficiency and adrenal insufficiency are underlying factors.
Impaired supply of adrenal-derived sulfated sterols such as DHEA sulfate may drive the disease process.
American Psychological Association (APA)
Seneff, Stephanie& Swanson, Nancy L.& Koenig, Gerald& Li, Chen. 2016. Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of Pathology Linked to G6PD Deficiency and Sulfomucins. Disease Markers،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1103790
Modern Language Association (MLA)
Seneff, Stephanie…[et al.]. Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of Pathology Linked to G6PD Deficiency and Sulfomucins. Disease Markers No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1103790
American Medical Association (AMA)
Seneff, Stephanie& Swanson, Nancy L.& Koenig, Gerald& Li, Chen. Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of Pathology Linked to G6PD Deficiency and Sulfomucins. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1103790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103790