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Is Urinary NGAL Determination Useful for Monitoring Kidney Function and Assessment of Cardiovascular Disease? A 12-Month Observation of Patients with Type 2 Diabetes
Joint Authors
Ceranowicz, Piotr
Kuśnierz-Cabala, Beata
Kuźniewski, Marek
Żyłka, Agnieszka
Gala-Błądzińska, Agnieszka
Gil, Krzysztof
Olszanecki, Rafał
Dumnicka, Paulina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Diabetic kidney disease (DKD) may start as glomerular or tubular damage.
We assessed kidney function during one-year-long observation of patients with type 2 diabetes mellitus (T2DM) after initiation of nephroprotective treatment, with emphasis on the changes in urinary neutrophil gelatinase-associated lipocalin (uNGAL), and evaluated the association between tubular damage and cardiovascular complications of T2DM.
Materials and Methods.
Adult T2DM patients (55) were assessed initially and 30 patients after 1 year.
Albumin and uNGAL and creatinine were measured in first morning urine.
Albumin/creatinine (uACR) and uNGAL/creatinine (uNCR) ratios were calculated.
Results.
In logistic regression, both uACR above 30 mg/g and uNCR the median (21.3 μg/g) were associated with cardiovascular complications, independently of classical risk factors and diabetes duration.
One year after initiation of treatment, a significant reduction in HbA1c was observed.
BMI and lipid profiles did not change.
Increase in serum creatinine and reduction in eGFR occurred, along with decrease in uNGAL and uNCR.
Increasing uNCR and uACR were associated with higher control HbA1c.
The increase in uNCR was more frequent in patients with hypertension.
Conclusions.
Better glycemic control in T2DM patients results in improved tubular function, as reflected by reduced uNCR and uNGAL.
First morning urine uNGAL and uNCR may be useful to assess renal function and cardiovascular risk, along with albuminuria and eGFR.
American Psychological Association (APA)
Żyłka, Agnieszka& Gala-Błądzińska, Agnieszka& Dumnicka, Paulina& Ceranowicz, Piotr& Kuźniewski, Marek& Gil, Krzysztof…[et al.]. 2016. Is Urinary NGAL Determination Useful for Monitoring Kidney Function and Assessment of Cardiovascular Disease? A 12-Month Observation of Patients with Type 2 Diabetes. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103794
Modern Language Association (MLA)
Żyłka, Agnieszka…[et al.]. Is Urinary NGAL Determination Useful for Monitoring Kidney Function and Assessment of Cardiovascular Disease? A 12-Month Observation of Patients with Type 2 Diabetes. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103794
American Medical Association (AMA)
Żyłka, Agnieszka& Gala-Błądzińska, Agnieszka& Dumnicka, Paulina& Ceranowicz, Piotr& Kuźniewski, Marek& Gil, Krzysztof…[et al.]. Is Urinary NGAL Determination Useful for Monitoring Kidney Function and Assessment of Cardiovascular Disease? A 12-Month Observation of Patients with Type 2 Diabetes. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103794
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103794