Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy
Joint Authors
Jiang, Jing
Cao, Donghui
You, Lili
Jia, Zhifang
Cao, Xueyuan
Wu, Xing
Wang, Chuan
Jin, Meishan
Wen, Simin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
DNA methyltransferase 1 (DNMT1) plays a pivotal role in maintaining DNA methylation status.
Polymorphisms of DNMT1 may modify the role of DNMT1 in prognosis of gastric cancer (GC).
Our aim was to test whether polymorphisms of DNMT1 gene were associated with overall survival of GC.
Four hundred and forty-seven GC patients who underwent radical tumorectomy were enrolled in the study.
Five tagging SNPs (rs10420321, rs16999593, rs2228612, rs2228611, and rs2288349) of the DNMT1 gene were genotyped by TaqMan assays.
Kaplan-Meier survival plots and Cox proportional hazard regression were used to analyze the associations between SNPs of DNMT1 and survival of GC.
Patients carrying rs2228611 GA/AA genotype tended to live longer than those bearing the GG genotype (HR 0.68, 95% CI: 0.51–0.91, P=0.007).
Further multivariate Cox regression analysis showed that rs2228611 was an independent prognostic factor (GA/AA versus GG: OR 0.67, 95% CI 0.49–0.91, P=0.010).
Nevertheless, other SNPs did not show any significant associations with survival of GC.
Polymorphisms of the DNMT1 gene may affect overall survival of GC.
The SNP rs2228611 has the potentiality to serve as an independent prognostic marker for GC patients.
American Psychological Association (APA)
Jia, Zhifang& Wu, Xing& Cao, Donghui& Wang, Chuan& You, Lili& Jin, Meishan…[et al.]. 2016. Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103796
Modern Language Association (MLA)
Jia, Zhifang…[et al.]. Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103796
American Medical Association (AMA)
Jia, Zhifang& Wu, Xing& Cao, Donghui& Wang, Chuan& You, Lili& Jin, Meishan…[et al.]. Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103796