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Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population
Joint Authors
Tang, Sai-sai
Cai, Meng-yun
Yang, Xi-li
Liu, Xin-guang
Xiong, Xing-dong
Cheng, Jie
Zheng, Bi-ying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
lincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD).
To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown.
Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibility to CAD.
Genotyping of four tagSNPs (rs9380586, rs4713998, rs6930083, and rs6931097) within lincRNA-p21 gene was performed in 615 CAD and 655 controls.
The haplotype analysis showed that the haplotype G-A-A-G (rs9380586-rs4713998-rs6930083-rs6931097) was statistically significantly associated with the reduced risk for CAD (OR = 0.78, P = 0.023).
Stratified analysis revealed that G-A-A-G haplotype was at a significantly lower risk for myocardial infarction (MI) (OR = 0.68, P = 0.010).
We also found that haplotype G-A-A-G had a more pronounced decreased risk for premature CAD or MI subjects (OR = 0.67, P = 0.017 for premature CAD, and OR = 0.65, P = 0.041 for premature MI, resp.).
Our data provide the first evidence that the G-A-A-G haplotype of lincRNA-p21 is associated with decreased risk of CAD and MI, particularly among premature CAD/MI in the Chinese Han population.
Further studies with more subjects and in diverse ethnic populations are warranted to clarify the general validity of our findings.
American Psychological Association (APA)
Tang, Sai-sai& Cheng, Jie& Cai, Meng-yun& Yang, Xi-li& Liu, Xin-guang& Zheng, Bi-ying…[et al.]. 2016. Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103804
Modern Language Association (MLA)
Tang, Sai-sai…[et al.]. Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103804
American Medical Association (AMA)
Tang, Sai-sai& Cheng, Jie& Cai, Meng-yun& Yang, Xi-li& Liu, Xin-guang& Zheng, Bi-ying…[et al.]. Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103804