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Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study
Joint Authors
Zeng, Xi
Zhang, Zhu
Gao, Qian-Qian
Wang, Yan-Yun
Yu, Xiu-Zhang
Zhou, Bin
Xi, Ming-Rong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
Previous evidence has proved that interleukin-31 (IL-31) and interleukin-33 (IL-33) can be potential markers in some cancers’ formulation.
We aimed to determine the potential role of IL-31 and IL-33 in prognosis of endometrial cancer patients.
Methods.
Serum samples were collected from 160 patients with endometrial cancer and 160 healthy controls.
The ELISA kits (Raybio® Systems) specific for human IL-31 and human IL-33 were used.
Serum levels of tumor markers (CEA, CA-125, and CA19-9) were measured by chemiluminescence immunoassay.
A two-side P value < 0.05 was indicated to be significant.
Results.
Serum levels of IL-31 and IL-33 in patients were significantly elevated compared to those of healthy controls.
The interleukin levels were also related to clinical characteristics, including tumor stages, depth of invasion, and existence of node metastases and distant metastases.
The sensitivity and specificity of IL-31 and IL-33 were higher than the counterparts of tumor markers, both separately and in combination of IL-31, IL-33, and the clinical markers.
Conclusions.
This report is the first one mentioning the possible association between serum IL-31 and IL-33 and endometrial cancer.
With their sensitivity and specificity, the interleukins may be useful biomarkers for endometrial cancer’s prognosis.
American Psychological Association (APA)
Zeng, Xi& Zhang, Zhu& Gao, Qian-Qian& Wang, Yan-Yun& Yu, Xiu-Zhang& Zhou, Bin…[et al.]. 2016. Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103816
Modern Language Association (MLA)
Zeng, Xi…[et al.]. Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103816
American Medical Association (AMA)
Zeng, Xi& Zhang, Zhu& Gao, Qian-Qian& Wang, Yan-Yun& Yu, Xiu-Zhang& Zhou, Bin…[et al.]. Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103816