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CEACAM1: Expression and Role in Melanocyte Transformation
Joint Authors
Zurac, Sabina
Jilaveanu, Lucia B.
Cioplea, Mirela
Turcu, Gabriela
Nedelcu, Roxana Ioana
Ion, Daniela Adriana
Brînzea, Alice
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metastases represent the main cause of death in melanoma patients.
Despite the current optimized targeted therapy or immune checkpoint inhibitors the treatment of metastatic melanoma is unsatisfactory.
Because of the poor prognosis of advanced melanoma there is an urgent need to identify new biomarkers to differentiate melanoma cells from normal melanocytes, to stratify patients according to their risk, and to identify subgroups of patients that require close follow-up or more aggressive therapy.
Furthermore, melanoma progression has been associated with the dysregulation of cell adhesion molecules.
We have reviewed the literature and have discussed the important role of the expression of the carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) in the development of melanoma.
Thus, novel insights into CEACAM1 may lead to promising strategies in melanoma treatment, in monitoring melanoma patients, in assessing the response to immunotherapy, and in completing the standard immunohistochemical panel used in melanoma examination.
American Psychological Association (APA)
Turcu, Gabriela& Nedelcu, Roxana Ioana& Ion, Daniela Adriana& Brînzea, Alice& Cioplea, Mirela& Jilaveanu, Lucia B.…[et al.]. 2016. CEACAM1: Expression and Role in Melanocyte Transformation. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103822
Modern Language Association (MLA)
Turcu, Gabriela…[et al.]. CEACAM1: Expression and Role in Melanocyte Transformation. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103822
American Medical Association (AMA)
Turcu, Gabriela& Nedelcu, Roxana Ioana& Ion, Daniela Adriana& Brînzea, Alice& Cioplea, Mirela& Jilaveanu, Lucia B.…[et al.]. CEACAM1: Expression and Role in Melanocyte Transformation. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103822