CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression

Joint Authors

Würsch, Daniela
Romero-Rodríguez, Dámaris P.
Olvera-García, Gustavo
Jiang, Wei
Pérez-Patrigeon, Santiago
Espinosa, Enrique
Ormsby, Christopher E.
Zuñiga, Joaquin

Source

Disease Markers

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-03-14

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

In order to determine if the expression of the activation marker CD38 can correlate with HIV disease progression independently of cycling, we performed a cluster-based multivariate correlation analysis of total circulating CD4+ T cell counts and viral loads with frequencies of CD38 and Ki67 expression on CD4+ lymphocytes from patients with untreated HIV infection, stratified in maturation subpopulations, and subpopulation subsets defined by the expression of CXCR5, CXCR3, and CCR4.

The frequencies of the activated phenotypes %CD38+ Ki67− and %CD38+ Ki67+ of the CXCR5− CXCR3− CCR4+ (“pre-Th2”) central memory ( T C M ) cell subset clustered together, comprising a significant negative correlate of total circulating CD4+ T cell counts and a positive correlate of viral load in multivariate analysis.

Frequency of cycling-uncoupled CD38 expression in “pre-Th2” T C M cells was a negative correlate of total circulating CD4+ T cell counts in univariate analysis, which was not the case of their %CD38+ Ki67+.

CXCR5+ CXCR3− CCR4− T C M cells were underrepresented in patients, and their absolute counts correlated negatively with their %CD38+ Ki67− but not with their % CD38+ Ki67+.

Our results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling.

American Psychological Association (APA)

Würsch, Daniela& Ormsby, Christopher E.& Romero-Rodríguez, Dámaris P.& Olvera-García, Gustavo& Zuñiga, Joaquin& Jiang, Wei…[et al.]. 2016. CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression. Disease Markers،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103824

Modern Language Association (MLA)

Würsch, Daniela…[et al.]. CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression. Disease Markers No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103824

American Medical Association (AMA)

Würsch, Daniela& Ormsby, Christopher E.& Romero-Rodríguez, Dámaris P.& Olvera-García, Gustavo& Zuñiga, Joaquin& Jiang, Wei…[et al.]. CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103824

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1103824