Interleukin-6-174GC Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies
Joint Authors
Yu, Hai-Yang
Guo, Bin
Zhu, Junfei
Fu, Min
Guo, Wushuang
Yuan, Yifang
Yuan, He
Zhang, Suhan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Introduction.
Chronic Periodontitis (CP) is suggested to be related to gene variations.
Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility.
Materials and Methods.
Pubmed, Embase, and Web of Science were searched up to May 2016.
The meta-analyses were performed using STATA 12.0.
Results.
21 studies were yielded.
Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560–0.849, P=0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568–0.838, P<0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577–0.980, P=0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576–0.944, P=0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497–0.845, P=0.001; GC versus GG: OR = 0.621, 95% CI = 0.441–0.876, P=0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470–0.896, P=0.009).
Conclusion.
IL-6 174 polymorphism is associated with CP susceptibility.
In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP.
American Psychological Association (APA)
Zhu, Junfei& Guo, Bin& Fu, Min& Guo, Wushuang& Yuan, Yifang& Yuan, He…[et al.]. 2016. Interleukin-6-174GC Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies. Disease Markers،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103826
Modern Language Association (MLA)
Zhu, Junfei…[et al.]. Interleukin-6-174GC Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies. Disease Markers No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103826
American Medical Association (AMA)
Zhu, Junfei& Guo, Bin& Fu, Min& Guo, Wushuang& Yuan, Yifang& Yuan, He…[et al.]. Interleukin-6-174GC Polymorphism Contributes to Periodontitis Susceptibility: An Updated Meta-Analysis of 21 Case-Control Studies. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103826