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Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer
Joint Authors
Brown-Glaberman, Ursa
Marron, Marilyn
Chalasani, Pavani
Livingston, Robert
Iannone, Maria
Specht, Jennifer
Stopeck, Alison T.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Carbonic anhydrase IX (CAIX) is a hypoxia regulated metalloenzyme integral to maintaining cellular pH.
Increased CAIX expression is associated with poor prognosis in breast cancer.
To explore CAIX as a biomarker for breast cancer therapies, we measured plasma CAIX levels in healthy control subjects and in breast cancer patients.
Methods.
In control subjects we evaluated plasma CAIX stability via commercially available ELISA.
We then similarly quantified plasma CAIX levels in (1) locally advanced breast cancer (LABC) patients treated with neoadjuvant paclitaxel + sunitinib (T + S) followed by doxorubicin and cyclophosphamide (AC); (2) metastatic breast cancer (MBC) patients treated with systemic chemotherapy.
Results.
Plasma CAIX levels were stable at room temperature for at least 48 hours in control subjects.
Mean baseline plasma CAIX levels were lower in controls compared to patients with LABC or MBC.
In LABC, CAIX levels rose significantly in response to administration of antiangiogenic therapy (T + S) ( p = 0.02 ) but not AC ( p = 0.37 ).
In patients with MBC treated without an antiangiogenic agent CAIX levels did not change with therapy.
Conclusions.
Our results suggest that CAIX may be an easily obtained, stable measure of tumor associated hypoxia as well as a useful pharmacodynamic biomarker for antiangiogenic therapy.
American Psychological Association (APA)
Brown-Glaberman, Ursa& Marron, Marilyn& Chalasani, Pavani& Livingston, Robert& Iannone, Maria& Specht, Jennifer…[et al.]. 2016. Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103827
Modern Language Association (MLA)
Brown-Glaberman, Ursa…[et al.]. Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103827
American Medical Association (AMA)
Brown-Glaberman, Ursa& Marron, Marilyn& Chalasani, Pavani& Livingston, Robert& Iannone, Maria& Specht, Jennifer…[et al.]. Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103827