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Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma
Joint Authors
Căruntu, Constantin
Căruntu, Ana
Costea, Daniela Elena
Greabu, Maria
Calenic, Bogdan
Voiculescu, Vlad
Ghita, Mihaela
Lupu, Mihai
Moraru, Liliana
Voiculescu, Suzana
Popa, Iris Maria
Rosca, Adrian E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Basal cell carcinoma (BCC) is the world’s leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences.
UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas.
Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement.
Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system.
Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.
American Psychological Association (APA)
Lupu, Mihai& Căruntu, Constantin& Ghita, Mihaela& Voiculescu, Vlad& Voiculescu, Suzana& Rosca, Adrian E.…[et al.]. 2016. Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103828
Modern Language Association (MLA)
Lupu, Mihai…[et al.]. Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103828
American Medical Association (AMA)
Lupu, Mihai& Căruntu, Constantin& Ghita, Mihaela& Voiculescu, Vlad& Voiculescu, Suzana& Rosca, Adrian E.…[et al.]. Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103828