![](/images/graphics-bg.png)
Ligustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1
Joint Authors
Liang, Qian-Qian
Liu, Shu-Fen
Bian, Qin
Zhao, Bizeng
Shi, Huipeng
Fu, Yishan
Xu, Leqin
Wang, Yongjun
Yang, Zhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CEP hypertrophy is one of the characteristics of intervertebral disc degeneration (IDD).
LIG exerts a protective effect on IDD in animal model.
The effect of LIG on CEP hypertrophy is further investigated in the present study.
Cells were isolated from hypertrophic samples obtained from patients during vertebral fusion surgery.
Cellular proliferation and the expression of type I collagen (Col I) and TGF-β1 were tested.
In the bipedal rats, the edges of the CEP and the sizes of noncartilaginous outgrowth, as well as the expression of osteogenic markers, Col1a, ALP, Runx2, and TGF-β1, were detected.
Within two passages, the condensed hypertrophic CEP cells exhibited osteogenic capacity by bony-like nodules and ALP positive staining, along with increased expression of Col I and TGF-β1.
LIG inhibited proliferation of CEP cells and downregulated the expression of Col I and TGF-β1 in vitro.
Furthermore, LIG attenuated CEP hypertrophy on the lumbar spine of bipedal rats by reducing Col1a, ALP, Runx2, and TGF-β1 mRNA expression and TGF-β1 distribution in vivo.
We concluded LIG exerted a preventive effect on CEP hypertrophy via suppression of TGF-β1 levels.
This information could be used to develop alternative therapeutic methods to treat spinal CEP hypertrophy.
American Psychological Association (APA)
Liu, Shu-Fen& Zhao, Bizeng& Shi, Huipeng& Liang, Qian-Qian& Fu, Yishan& Yang, Zhu…[et al.]. 2016. Ligustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103880
Modern Language Association (MLA)
Liu, Shu-Fen…[et al.]. Ligustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103880
American Medical Association (AMA)
Liu, Shu-Fen& Zhao, Bizeng& Shi, Huipeng& Liang, Qian-Qian& Fu, Yishan& Yang, Zhu…[et al.]. Ligustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103880