Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity of Paullinia cupana Seeds Crude Extract and Ethyl-Acetate Fraction
Joint Authors
Pitta, Ivan da Rocha
de Melo Rego, Moacyr Jesus Barreto
Sampaio, Maria Clara Pinheiro Duarte
Carvalho, Lidiane Vasconcelos do Nascimento
Cordeiro, Marina Ferraz
e Lins, Thiago Ubiratan Lins
de Mello, Gabriela Souto Vieira
da Costa, Valécia de Cassia Mendonça
Marques, Leila Larisa Medeiros
Klein, Traudi
de Mello, João Carlos Palazzo
Cavalcanti, Isabella Macário Ferro
Pitta, Maira Galdino da Rocha
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Paullinia cupana (Guarana) is a native plant of Amazon region that has very traditional importance.
Its seeds are rich in bioactive compounds, including tannins, which exhibit relevant properties.
Objective.
This study aimed to evaluate antibacterial, antineoplastic, and immunomodulatory activity of P.
cupana seeds crude extract (CE) and ethyl-acetate fraction (EAF).
Methods.
Antibacterial activity was evaluated by determination of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).
Antineoplastic activity was evaluated by MTT assays in hepatocellular carcinoma (HepG2), breast adenocarcinoma (MCF-7), ductal carcinoma (T47-D), non-Hodgkin’s B cell lymphoma (Toledo), T cell leukemia (Jukart), and Acute Leukemia (HL-60) cell lines.
BALB/c mice splenocytes were treated to assess IFN-γ, IL-6, IL-17, and IL-10 levels by sandwich ELISA.
Results.
CE and EAF were not toxic to peripheral blood cells and splenocytes.
CE and EAF fractions showed a bacteriostatic activity (MIC = 250 μg/mL) and presented IC50 values of 70.25 μg/mL and 61.18 μg/mL in HL-60 leukemia cell line.
All cytokines evaluated had their levels reduced after treatment, following dose-response model.
Discussion and Conclusion.
Different biological activities were observed for both CE and EAF, suggesting P.
cupana as a source of bioactive substances, especially tannins that may be used for several diseases treatments.
American Psychological Association (APA)
Carvalho, Lidiane Vasconcelos do Nascimento& Cordeiro, Marina Ferraz& e Lins, Thiago Ubiratan Lins& Sampaio, Maria Clara Pinheiro Duarte& de Mello, Gabriela Souto Vieira& da Costa, Valécia de Cassia Mendonça…[et al.]. 2016. Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity of Paullinia cupana Seeds Crude Extract and Ethyl-Acetate Fraction. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103889
Modern Language Association (MLA)
Carvalho, Lidiane Vasconcelos do Nascimento…[et al.]. Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity of Paullinia cupana Seeds Crude Extract and Ethyl-Acetate Fraction. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103889
American Medical Association (AMA)
Carvalho, Lidiane Vasconcelos do Nascimento& Cordeiro, Marina Ferraz& e Lins, Thiago Ubiratan Lins& Sampaio, Maria Clara Pinheiro Duarte& de Mello, Gabriela Souto Vieira& da Costa, Valécia de Cassia Mendonça…[et al.]. Evaluation of Antibacterial, Antineoplastic, and Immunomodulatory Activity of Paullinia cupana Seeds Crude Extract and Ethyl-Acetate Fraction. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103889