GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn

Joint Authors

Khan, Imran
Karim, Nasiara
Ahmad, Waqar
Abdelhalim, Abeer
Chebib, Mary

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-04-07

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Artemisia indica, also known as “Mugwort,” has been widely used in traditional medicines.

However, few studies have investigated the effects of nonvolatile components of Artemisia indica on central nervous system’s function.

Fractionation of Artemisia indica led to the isolation of carnosol, ursolic acid, and oleanolic acid which were evaluated for their effects on GABA-A receptors in electrophysiological studies in Xenopus oocytes and were subsequently investigated in mouse models of acute toxicity, convulsions (pentylenetetrazole induced seizures), depression (tail suspension and forced swim tests), and anxiety (elevated plus maze and light/dark box paradigms).

Carnosol, ursolic acid, and oleanolic acid were found to be positive modulators of α1β2γ2L GABA-A receptors and the modulation was antagonized by flumazenil.

Carnosol, ursolic acid, and oleanolic acid were found to be devoid of any signs of acute toxicity (50–200 mg/kg) but elicited anticonvulsant, antidepressant, and anxiolytic activities.

Thus carnosol, ursolic acid, and oleanolic acid demonstrated CNS activity in mouse models of anticonvulsant, antidepressant, and anxiolysis.

The anxiolytic activity of all three compounds was ameliorated by flumazenil suggesting a mode of action via the benzodiazepine binding site of GABA-A receptors.

American Psychological Association (APA)

Khan, Imran& Karim, Nasiara& Ahmad, Waqar& Abdelhalim, Abeer& Chebib, Mary. 2016. GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103894

Modern Language Association (MLA)

Khan, Imran…[et al.]. GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103894

American Medical Association (AMA)

Khan, Imran& Karim, Nasiara& Ahmad, Waqar& Abdelhalim, Abeer& Chebib, Mary. GABA-A Receptor Modulation and Anticonvulsant, Anxiolytic, and Antidepressant Activities of Constituents from Artemisia indica Linn. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103894

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1103894