Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats

Joint Authors

Seo, Chang-Seob
Park, In-Kyu
Choi, Donghee
Na, Changsu
Kim, Wangin
Park, Sangbin
Choi, Chanhun
Kim, Youg Ran
Youn, Daehwan
Shin, Wook
Lee, Yumi
Kim, Mirae
Lee, Hyunju
Kim, Seonjong

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-06-13

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Ganghwaljetongyeum (GHJTY) has been used as a standard treatment for arthritis for approximately 15 years at the Korean Medicine Hospital of Dongshin University.

GHJTY is composed of 18 medicinal herbs, of which five primary herbs were selected and named new Ganghwaljetongyeum (N-GHJTY).

The purpose of the present study was to observe the effect of N-GHJTY on arthritis and to determine its mechanism of action.

After confirming arthritis induction using complete Freund’s adjuvant (CFA) in rats, N-GHJTY (62.5, 125, and 250 mg/kg/day) was administered once a day for 10 days.

In order to determine pathological changes, edema of the paws and weight were measured before and for 10 days after N-GHJTY administration.

Cytokine (TNF-α, IL-1β, and IL-6) levels and histopathological lesions in the knee joint were also examined.

Edema in the paw and knee joint of N-GHJTY-treated rats was significantly decreased at 6, 8, and 10 days after administration, compared to that in the CFA-control group, while weight consistently increased.

Rats in N-GHJTY-treated groups also recovered from the CFA-induced pathological changes and showed a significant decline in cytokine levels.

Taken together, our results showed that N-GHJTY administration was effective in inhibiting CFA-induced arthritis via anti-inflammatory effects while promoting cartilage recovery by controlling cytokine levels.

American Psychological Association (APA)

Kim, Wangin& Park, Sangbin& Choi, Chanhun& Kim, Youg Ran& Park, In-Kyu& Seo, Chang-Seob…[et al.]. 2016. Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103895

Modern Language Association (MLA)

Kim, Wangin…[et al.]. Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103895

American Medical Association (AMA)

Kim, Wangin& Park, Sangbin& Choi, Chanhun& Kim, Youg Ran& Park, In-Kyu& Seo, Chang-Seob…[et al.]. Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103895

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1103895