Effects of Xiaoyaosan on Stress-Induced Anxiety-Like Behavior in Rats: Involvement of CRF1 Receptor
Joint Authors
Jiang, You-Ming
Li, Xiao-Juan
Yan, Zhi-Yi
Meng, Zhen-Zhi
Zhao, Hong-Bo
Li, Na
Ma, Qing-Yu
Zhang, Han-Ting
Liu, Yue-Yun
Chen, Jia-Xu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Compared with antidepressant activity of Xiaoyaosan, the role of Xiaoyaosan in anxiety has been poorly studied.
Objective.
To observe the effects of Xiaoyaosan on anxiety-like behavior induced by chronic immobilization stress (CIS) and further explore whether these effects were related to CRF1R signaling.
Methods.
Adult male SD rats were randomly assigned to five groups ( n = 12 ): the nonstressed control group, vehicle-treated (saline, p.o.) group, Xiaoyaosan-treated (3.854 g/kg, p.o.) group, vehicle-treated (surgery) group, and antalarmin-treated (surgery) group.
Artificial cerebrospinal fluid (0.5 μL/side) or CRF1R antagonist antalarmin (125 ng/0.5 μL, 0.5 μL/side) was bilaterally administered into the basolateral amygdala in the surgery groups.
Except for the nonstressed control group, the other four groups were exposed to CIS (14 days, 3 h/day) 30 minutes after treatment.
On days 15 and 16, all animals were subjected to the elevated plus-maze (EPM) and novelty suppressed feeding (NSF) test.
We then examined the expression of CRF1R, pCREB, and BDNF in the amygdala.
Results.
Chronic pretreatment with Xiaoyaosan or antalarmin significantly reversed elevated anxiety-like behavior and the upregulated level of CRF1R and BDNF in the amygdala of stressed rats.
pCREB did not differ significantly among the groups.
Conclusions.
These results suggest that Xiaoyaosan exerts anxiolytic-like effects in behavioral tests and the effects may be related to CRF1R signaling in the amygdala.
American Psychological Association (APA)
Jiang, You-Ming& Li, Xiao-Juan& Meng, Zhen-Zhi& Liu, Yue-Yun& Zhao, Hong-Bo& Li, Na…[et al.]. 2016. Effects of Xiaoyaosan on Stress-Induced Anxiety-Like Behavior in Rats: Involvement of CRF1 Receptor. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103896
Modern Language Association (MLA)
Jiang, You-Ming…[et al.]. Effects of Xiaoyaosan on Stress-Induced Anxiety-Like Behavior in Rats: Involvement of CRF1 Receptor. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103896
American Medical Association (AMA)
Jiang, You-Ming& Li, Xiao-Juan& Meng, Zhen-Zhi& Liu, Yue-Yun& Zhao, Hong-Bo& Li, Na…[et al.]. Effects of Xiaoyaosan on Stress-Induced Anxiety-Like Behavior in Rats: Involvement of CRF1 Receptor. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103896