PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats
Joint Authors
Cui, Xiaopei
Feng, Hua
Xu, Xia
Li, Haijun
Zhang, Hongyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
To investigate the effect of Tongxinluo (Txl), a Chinese herbal compound, on diabetic peripheral neuropathy (DPN).
Methods and Results.
Diabetic rat model was established by peritoneal injection of streptozotocin (STZ).
Txl ultrafine powder treatment for 16 weeks from the baseline significantly reversed the impairment of motor nerve conductive velocity (MNCV), mechanical hyperalgesia, and nerve structure.
We further proved that Tongxinluo upregulates PGC-1α and its downstream factors including COX IV and SOD, which were involved in mitochondrial biogenesis.
Conclusion.
Our study indicates that the protective effect of Txl in diabetic neuropathy may be attributed to the induction of PGC-1α and its downstream targets.
This finding may further illustrate the pleiotropic effect of the medicine.
American Psychological Association (APA)
Cui, Xiaopei& Feng, Hua& Xu, Xia& Li, Haijun& Zhang, Hongyu. 2016. PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103898
Modern Language Association (MLA)
Cui, Xiaopei…[et al.]. PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103898
American Medical Association (AMA)
Cui, Xiaopei& Feng, Hua& Xu, Xia& Li, Haijun& Zhang, Hongyu. PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103898