Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases
Joint Authors
Zhao, Ruxing
Sun, Yu
Li, Wen-juan
He, Tianyi
Lu, Yiran
Hou, Xinguo
Dong, Ming
Chen, Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD).
Methods.
44 Patients with Graves’s disease (GD) and 56 patients with Hashimoto’s thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct).
The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups.
Thyroid hormones, thyroid antibodies, and T lymphocyte subsets were quantified at baseline and 24 weeks posttreatment.
Results.
Significant drop of serum anti-TPO-Ab levels was observed in both GD-Tx and HT-Tx groups.
Before treatment, GD patients had higher helper T cells compared to cytotoxic T cells, while HT patients suffered from a nearly inverted proportion of helper T/cytotoxic T cells.
There was a significant drop of the helper T/cytotoxic T cells ratio in GD-Tx to the median of the normal ranges after Corbrin treatment for 24 weeks, while that in HT-Tx was elevated.
Conclusion.
Corbrin Capsule could restore the balance between helper T and cytotoxic T cells in both GD and HT patients with dual-directional immunomodulatory effects.
And it could significantly reduce the autoantibody levels in both GD and HT.
American Psychological Association (APA)
He, Tianyi& Zhao, Ruxing& Lu, Yiran& Li, Wen-juan& Hou, Xinguo& Sun, Yu…[et al.]. 2016. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103901
Modern Language Association (MLA)
He, Tianyi…[et al.]. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103901
American Medical Association (AMA)
He, Tianyi& Zhao, Ruxing& Lu, Yiran& Li, Wen-juan& Hou, Xinguo& Sun, Yu…[et al.]. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103901